Fluoride ion (2024)

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Generic Name
Fluoride ion
DrugBank Accession Number
DB11257
Background

Having a chemical formula of F−, fluoride ion is the simplest inorganic, monatomic anion of fluorine with basic properties. It is considered a trace element. Fluoride ions are found in various minerals but are only present in trace amounts in water. Its various salt forms and minerals play numerous roles as chemical reagents, industrial chemicals, and commercial products. It also plays an essential physiological role, such as enhancing the resistance profile and strength of the surface tooth enamel.

Type
Small Molecule
Groups
Approved
Structure

Fluoride ion (1)

Structure for Fluoride ion (DB11257)

Fluoride ion (2)

Weight
Average: 18.9984
Monoisotopic: 18.998403205
Chemical Formula
F
Synonyms
Not Available

Pharmacology

Indication

Not Available

Fluoride ion (4)

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Prophylaxis ofDental cavity•••••••••••••••
Used in combination to preventHypovitaminosis dCombination Product in combination with: Cholecalciferol (DB00169)••••••••••••••••••••••••
Contraindications & Blackbox Warnings

Fluoride ion (5)

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

Fluoride ion (6)

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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Not Available
Food Interactions
No interactions found.

Products

Fluoride ion (7)

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Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Topex Neutral pH Fluoride Gel MintGel9 mg/1gDentalDentsply Llc. Professional Division Trading As "Sultan Healthcare"1974-01-01Not applicableFluoride ion (8)
Topex Neutral pH Fluoride Gel StrawberryGel9 mg/1gDentalDentsply Llc. Professional Division Trading As "Sultan Healthcare"1974-01-012023-08-18Fluoride ion (9)
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
D FLUORETTEN 500Fluoride ion (0.25 mg/1) + Cholecalciferol (500 IU/1)Tablet2006-07-01Not applicableFluoride ion (10)
D FLUORETTEN 500Fluoride ion (0.25 mg/1) + Cholecalciferol (500 IU/1)Tablet2006-07-01Not applicableFluoride ion (11)
ZYMAFLUOR D 1000Fluoride ion (0.25 mg) + Cholecalciferol (1000 IU)Tablet2006-07-01Not applicableFluoride ion (12)
ZYMAFLUOR D 500Fluoride ion (0.25 mg) + Cholecalciferol (500 IU)Tablet2006-07-01Not applicableFluoride ion (13)
ZYMAFLUOR D 500Fluoride ion (0.25 mg) + Cholecalciferol (500 IU)Tablet2006-07-01Not applicableFluoride ion (14)
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Multi-VitaminFluoride ion (1.0 mg/1) + Ascorbic acid (60 mg/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Niacin (13.5 mg/1) + Pyridoxine (1.05 mg/1) + Riboflavin (1.2 mg/1) + Thiamine chloride (1.05 mg/1) + Vitamin A (2500 [iU]/1) + Vitamin D (400 [iU]/1)Tablet, chewableOralBoca Pharmacal, Inc.2011-09-062014-12-31Fluoride ion (15)
Multi-VitaminFluoride ion (0.50 mg/1) + Ascorbic acid (60 mg/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Niacin (13.5 mg/1) + Pyridoxine (1.05 mg/1) + Riboflavin (1.2 mg/1) + Thiamine chloride (1.05 mg/1) + Vitamin A (2500 [iU]/1) + Vitamin D (400 [iU]/1)Tablet, chewableOralBoca Pharmacal, Inc.2011-12-282015-06-30Fluoride ion (16)
Multi-Vitamin Fluoride and Iron DropsFluoride ion (0.25 mg/1mL) + Ascorbic acid (35 mg/1mL) + Cholecalciferol (400 [iU]/1mL) + Iron (10 mg/1mL) + Niacin (8 mg/1mL) + Pyridoxine (0.4 mg/1mL) + Riboflavin (0.6 mg/1mL) + Thiamine chloride (0.5 mg/1mL) + Vitamin A (1500 [iU]/1mL) + alpha-Tocopherol succinate (5 [iU]/1mL)SolutionOralBoca Pharmacal, Inc.2011-04-202015-08-31Fluoride ion (17)
Multi-Vitamin Fluoride DropsFluoride ion (0.25 mg/1mL) + Ascorbic acid (35 mg/1mL) + Cholecalciferol (400 [iU]/1mL) + Cyanocobalamin (2 ug/1mL) + Niacin (8 mg/1mL) + Pyridoxine (0.4 mg/1mL) + Riboflavin (0.6 mg/1mL) + Thiamine chloride (0.5 mg/1mL) + Vitamin A (1500 [iU]/1mL) + alpha-Tocopherol succinate (5 [iU]/1mL)SolutionOralH.J. Harkins Company2011-05-04Not applicableFluoride ion (18)
Multi-Vitamin Fluoride DropsFluoride ion (0.5 mg/1mL) + Ascorbic acid (35 mg/1mL) + Cholecalciferol (400 [iU]/1mL) + Cyanocobalamin (2 ug/1mL) + Niacin (8 mg/1mL) + Pyridoxine (0.4 mg/1mL) + Riboflavin (0.6 mg/1mL) + Thiamine chloride (0.5 mg/1mL) + Vitamin A (1500 [iU]/1mL) + alpha-Tocopherol succinate (5 [iU]/1mL)SolutionOralBoca Pharmacal, Inc.2011-06-062015-08-31Fluoride ion (19)

Categories

Drug Categories

Not Available

Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as hom*ogeneous halogens. These are inorganic non-metallic compounds in which the largest atom is a nobel gas.
Kingdom
Inorganic compounds
Super Class
hom*ogeneous non-metal compounds
Class
hom*ogeneous halogens
Sub Class
Not Available
Direct Parent
hom*ogeneous halogens
Alternative Parents
Not Available
Substituents
hom*ogeneous halogen
Molecular Framework
Not Available
External Descriptors
halide anion, monoatomic fluorine (CHEBI:17051) / an anion (F-)
Affected organisms
Not Available

Chemical Identifiers

UNII
Q80VPU408O
CAS number
16984-48-8
InChI Key
KRHYYFGTRYWZRS-UHFFFAOYSA-M
InChI

InChI=1S/FH/h1H/p-1

IUPAC Name

fluoride

SMILES

[F-]

References

General References
Not Available
External Links
Human Metabolome Database
HMDB0000662
KEGG Compound
C00742
PubChem Compound
28179
PubChem Substance
347827955
ChemSpider
26214
BindingDB
26978
RxNav
196213
ChEBI
17051
ChEMBL
CHEMBL1362
PDBe Ligand
F
Wikipedia
Fluoride
PDB Entries
1bs3 / 1e6a / 1lh5 / 1nel / 1t5g / 2akz / 2au6 / 2au9 / 2auu / 2dqz show 83 more

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms
FormRouteStrength
Injection, solution, concentrateIntravenous
Tablet
Tablet, chewableOral
SolutionOral
Suspension / dropsOral
GelDental9 mg/1g
Gel
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0.15Chemaxon
pKa (Strongest Acidic)3.17Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count0Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area0 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity0.87 m3·mol-1Chemaxon
Polarizability0.44 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-108.0462

predicted

DeepCCS 1.0 (2019)
[M-H]-108.0462

predicted

DeepCCS 1.0 (2019)
[M+H]+109.7789

predicted

DeepCCS 1.0 (2019)
[M+H]+109.7789

predicted

DeepCCS 1.0 (2019)
[M+Na]+116.56366

predicted

DeepCCS 1.0 (2019)
[M+Na]+116.56366

predicted

DeepCCS 1.0 (2019)

Fluoride ion (20)

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Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53

Fluoride ion (2024)

FAQs

What is the ions of fluoride? ›

Having a chemical formula of F−, fluoride ion is the simplest inorganic, monatomic anion of fluorine with basic properties.

How many protons does F − have? ›

How many electrons does F+ have? ›

Flexi Says: Fluorine has a total of 9 electrons. Thus, fluoride ion will have 9 + 1 = 10 electrons.

What is the recommended concentration of fluoride ion? ›

The recommended concentration of fluoride ion in drinking water is up to 1 ppm as fluoride ions are required to make teeth enamel harder by converting [3Ca3(PO4)2.Ca(OH)2] to.

What charge ion is fluoride? ›

A fluorine atom has nine protons and nine electrons, so it is electrically neutral. If a fluorine atom gains an electron, it becomes a fluoride ion with an electric charge of -1.

Is fluoride ion strong or weak? ›

Fluoride is classified as a weak base since it only partially associates in solution, but concentrated fluoride is corrosive and can attack the skin. Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Fluoride is the simplest fluorine anion.

What is fluorine made of? ›

It is the 13th most common element in the Earth's crust. Fluorine is made by the electrolysis of a solution of potassium hydrogendifluoride (KHF2) in anhydrous hydrofluoric acid.

How does fluorine bond? ›

The high electronegativity of fluorine means that it forms a single electron pair bond polar bond with a high ionic character. The polar nature of the bond means that there is a large inductive effect within a molecule. For example, perfluoroethanol (CF3CF2OH) has an acidity comparable to acetic acid.

What group is fluorine in? ›

Fluorine (F) is the first element in the Halogen group (group 17) in the periodic table. Its atomic number is 9 and its atomic weight is 19, and it's a gas at room temperature.

How many rings does fluorine have? ›

Fluorine has 9 electrons arranged in two shells around the nucleus. The first shell contains two electrons, and the second shell contains seven electrons. The electronic configuration of fluorine indicates that it has two electrons in the 1s orbital, two in the 2s orbital, and five in the 2p orbital.

How much fluoride is enough? ›

How much fluoride do I need?
Life StageRecommended Amount
Adult men 19+ years4 mg
Adult women 19+ years3 mg
Pregnant teens and women3 mg
Breastfeeding teens and women3 mg
6 more rows
Mar 22, 2021

What is a good fluoride level? ›

How Much Fluoride Is Needed to Prevent Tooth Decay? The U.S. Department of Health and Human Services recommends a level of 0.7 milligrams per Liter (mg/L) of fluoride in your drinking water. This is the level that prevents tooth decay and promotes good oral health.

Is 500 ppm fluoride enough? ›

The guidelines recommend low fluoride toothpaste (500ppm). Please ignore all the different ages ranges on the tubes of toothpaste below, they all contain the same amount of fluoride (500ppm). They are adequate for children ages 18 months-5 years with a LOW decay risk.

What are the ions in sodium fluoride? ›

Sodium fluoride is an inorganic ionic compound, dissolving in water to give separated Na+ and F ions.

What is the name of K+? ›

Potassium Cation | K+ | CID 813 - PubChem.

What is the most likely ion of fluorine? ›

F-, the fluoride ion.

What are the ions in caf2? ›

Calcium fluoride (CaF2) is an insoluble ionic compound composed of Ca2+ and F ions.

References

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